8 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... , autoimmune disorder ... negative anti-lgG ... CLL (older) • Autoimmune ... younger pts) Differential
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
Neutropenia - Differential ... Maternal hypertension and ... Constitutional disorders, eg ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare
Vancomycin induced Leukocytoclastic Vasculitis (LCV) of the Hand
70 M vertebral osteomyelitis on vancomycin and cefepime for
Vasculitis (LCV) of the Hand ... Differential for ... , foods, autoimmune ... Vasculitis #LCV #Hand ... dermatology #clinical #photo
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... arthralgia, arm/leg ... occasional oligoclonal bands ... purpura (lower legs
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... disease • Non-autoimmune ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
very remarkable w/differential ... vasculitis vs infection ... variably: On one hand ... systemic complaints- anemia ... required due to skip
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Tenderness → Consider infectious ... ) • Anti-Mi2 (skin ... • Mechanic's hands ... #rheumatology #differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
skin changes (POEMS ... syndrome) • Solitary ... Include: • Viral infections ... Cirrhosis, ETOH, autoimmune ... Gap #ProteinGap #differential