2203 results
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... Severe ALT > 15x ULN ... Moderate ALT 5-15x ULN ... Mild ALT < 5x ULN ... #LiverEnzymes #Differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Severe - ALT >15X ULN ... Moderate - ALT 5-15X ULN ... Mild - ALT < 5x ULN
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
value = (ALT + ULN ... phosphatase + ULN ... Transaminitis #diagnosis #differential
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
CK: Up to 50X ULN ... CK: Up to 50X ULN ... Proximal • CK: >50X ULN ... CK: Up to 10x ULN ... Inflammatory #Myopathies #differential
Causes of Common Accidental and Non-Accidental Pediatric Fractures - Differential Diagnosis Algorithm
Accidental Trauma
 - Distal Radius
Pediatric Fractures - Differential ... Skull, Spine, Ulna ... Fractures #Locations #Differential
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
likely - Mid range/ULN ... Hypercalcemia #workup #differential
Peritonitis - Spontaneous vs Secondary vs Peritoneal Dialysis Associated Peritonitis
Spontaneous Bacterial Peritonitis
 • Cirrhosis (high SAAG)
glucose < 50, LDH ULN ... Peritoneal #diagnosis #differential
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
AST/ALT (5-10x ULN ... infiltration) Differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... chemistry #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
• ALP > 1.5 x ULN ... bile ducts Differential