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diagnosis management oncology differential agglutinin aplastic autoimmune classification cold common cvid disease erythematosus gap globulin hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... - Clinical Presentation ... Weight loss • Anemia ... Immune hemolytic anemia ... classification #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
originate from a low-grade ... - Monoclonal - Lymphoid ... Viral Infection Clinical ... - Mycoplasma, EBV ... #hematology #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... Clinical Presentation ... and petechiae Causes ... may result from low ... #oncology #hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Major Clinical Trials ... Blood saves lives ... unnecessary and cause ... /vmoitra) #EBM ... Transfusion #Thresholds #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... • Nodules • Lymphoid ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Cytopenia -> BM ... -> AML: Blast crises ... - infiltrates (anemia ... response to mosquito bites ... #Leukemia #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Amyloidosis • Lymphoma ... acute HIV, HBV, EBV ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... PLT • Anemia of ... Erythematosus #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... or ALS • Very slow ... • ANA < 20 % IBM ... statins - probably caused ... Myositis #Myopathy #rheumatology
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