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diagnosis management myasthenia neurology antibodies antinxp2 antinxp2dm associations autoantibodies causes dermatology diseases endocrinology erythematosus hyperthyroidism lupus signs sle symptoms systemic
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Polymyositis / Dermatomyositis ... syndrome Anti-TSHR - Graves ... - Vasculitis, e.g ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... an autoimmune disease ... serologic, and EMG ... characteristic EMG ... #Myasthenia #Gravis
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... Neck: “dropping ... life-threatening Differential ... Serologic and EMG ... immunologic assay - MuSK
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
Hyperdefecation • Anterior neck ... diffuse goiter (Graves ... antibodies (TRAb) if Graves ... ' disease is suspected ... causes #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... , dermatomyositis ... Non-autoimmune rheumatologic ... Joint pain • Swan neck ... Erythematosus #Diagnosis #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
weakness in the neck ... , and back and shoulders ... had more severe disease ... positive patients Treatment ... diagnosis #management #rheumatology
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