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differential myositis vasculitis allergic allergy cryoglobulinemia cryoglobulins definitions erythematosus gap globulin hematology hypersensitivity lupus management myopathy protein proteingap reactions sjogrens
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
surfaces • Ex: Autoimmune ... Erythematosus, Reactive Arthritis ... Stevens-Johnson Syndrome ... #Classification ... #Diagnosis #Definitions
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
infection • Autoimmune ... Secondary to Autoimmune ... Labs/Diagnosis: ... #types #classification ... #rheumatology #
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... , holster sign, ... anti-synthetase syndrome ... myositis, and arthritis ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... rheumatologic diseases ... Kikuchi disease • Type-I ... pain • Swan neck/Ulnar ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Diagnosis: • Dry ... IV RTA, TYPE I ... Arthralgia and Arthritis ... #Rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... • Cogan Syndrome ... purpura: strong sign ... #rheumatology # ... classification
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... • Nonerosive arthritis ... Myositis #Myopathy #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... (RA, Temporal arteritis ... Cirrhosis, ETOH, autoimmune ... Comment on type ... #differential #diagnosis
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