15 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... Bilirubin • Unconjugated ... #Bilirubin #Metabolism ... #hepatology #Liver
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
(MALA) Pathophysiology ... cycle found in the liver ... use in cellular metabolism ... via anaerobic metabolism ... of metabolic acidosis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
and Bilirubin Metabolism ... insult Bilirubin metabolism ... cytochromes) • Unconjugated ... Tests #Laboratory #Metabolism ... Bilirubin #Hepatology #Pathophysiology
Clinical manifestations of acute liver failure 

Brain: 
Hepatic encephalopathy,  
Cerebral edema,  
Intracranial hypertension,
manifestations of acute liver ... abnormalities Liver ... : Loss of metabolic ... Coagulopathy, Lactic acidosis ... failure #Signs #Symptoms
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... postpartum): • Initial symptoms ... diagnosis #management #pathophysiology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... lipolysis Signs/Symptoms ... thickness) - metabolic ... endocrinology #pathophysiology
Lactic Acidosis - Differential Diagnosis Framework

Type A: Impaired O2 Delivery (DO2)
 • Decreased O2 Delivery: Hypotension
Lactic Acidosis ... Clearance: Systemic liver ... Inborn Errors of Metabolism ... Presents as AG acidosis ... Differential #Diagnosis #criticalcare
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
• Labs: - Metabolic ... acidosis - Rhabdomyolysis ... Collapse: • Pathophysiology ... Syncope • Signs/Symptoms ... - Mild lactic acidosis
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
depressed) • Renal: metabolic ... acidosis, oliguria ... AI, thyroid dz liver ... management #Overview #criticalcare