781 results
Bilirubin Metabolism - Pathophysiology
 • Conjugated Bilirubin
 • Unconjugated Bilirubin

By Dr. Khushboo Gala @LouLectures

#Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism - Pathophysiology ... • Conjugated ... Bilirubin • Unconjugated ... Bilirubin #Metabolism #Pathophysiology
Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... #Jaundice #Pathophysiology ... #Differential #Unconjugated
Biochemistry and Metabolism of Bilirubin
Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
→ Biliverdin → Unconjugated ... Conjugation → Conjugated ... common bile duct Unconjugated ... bilirubin, and conjugated ... Biochemistry #Metabolism #pathophysiology
Inherited forms of Hyperbilirubinemia
Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
for transporting unconjugated ... Decreased UGT1A1 - Unconjugated ... absent UGT1A1 - Unconjugated ... Decreased MRP2 - Conjugated ... Hyperbilirubinemia #pathophysiology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
cytochromes) • Unconjugated ... MRP2 transports conjugated ... Bilirubin #Hepatology #Pathophysiology
Algorithm and Differential Diagnosis of Hyperbilirubinemia 
Direct = Conjugated
Indirect = Unconjugated

#Diagnosis #Jaundice #Hyperbilirubinemia #Differential #Algorithm #Direct
Hyperbilirubinemia Direct = Conjugated ... Indirect = Unconjugated ... Direct #Indirect #Conjugated ... #Unconjugated #
Jaundice Evaluation Algorithm #Diagnosis #Management #EM #IM #GI #Jaundice #Hyperbilirubinemia #Workup #Evaluation #Differential #Algorithm #Direct #Indirect
Direct #Indirect #Conjugated ... #Unconjugated #
Causes of Jaundice - Prehepatic, Intrahepatic, Extrahepatic

#Diagnosis #Differential #Jaundice #Prehepatic #Intrahepatic #Extrahepatic #Unconjugated #Conjugated

** GrepMed Recommended
#Extrahepatic #Unconjugated ... #Conjugated
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
Bilirubin - Unconjugated ... Indirect) - Conjugated
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
, intermittent unconjugated ... UGT1A1 activity • Unconjugated ... an increase in conjugated ... and unconjugated ... • Increase in conjugated