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Algorithm and Differential Diagnosis of Hyperbilirubinemia Direct = Conjugated Indirect = Unconjugated #Diagnosis #Jaundice #Hyperbilirubinemia #Differential #Algorithm #Direct
Hyperbilirubinemia Direct = Conjugated ... Indirect = Unconjugated ... Direct #Indirect #Conjugated ... #Unconjugated #
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
Bilirubin - Unconjugated ... Indirect) - Conjugated ... Laboratory #Diagnosis #Testing
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Pathophysiology • Conjugated ... Bilirubin • Unconjugated
Jaundice Evaluation Algorithm #Diagnosis #Management #EM #IM #GI #Jaundice #Hyperbilirubinemia #Workup #Evaluation #Differential #Algorithm #Direct #Indirect
Direct #Indirect #Conjugated ... #Unconjugated #
Causes of Jaundice - Prehepatic, Intrahepatic, Extrahepatic #Diagnosis #Differential #Jaundice #Prehepatic #Intrahepatic #Extrahepatic #Unconjugated #Conjugated ** GrepMed Recommended
#Extrahepatic #Unconjugated ... #Conjugated
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
→ Biliverdin → Unconjugated ... Conjugation → Conjugated ... common bile duct Unconjugated ... bilirubin, and conjugated
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Laboratory Testing ... Reticulocytes Unconjugated ... Anemia #Laboratory #Testing
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
, intermittent unconjugated ... UGT1A1 activity • Unconjugated ... an increase in conjugated ... and unconjugated ... • Increase in conjugated
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Pre-Hepatic - Unconjugated ... II) Hepatic - Conjugated
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice Unconjugated ... drug reactions) Conjugated ... Classification #diagnosis #conjugated ... #unconjugated #
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