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diagnosis clinical differential management radiology dermatology hematology causes congenital derm laboratory melanoma pathophysiology signs skinrash symptoms tumor acquired adenosine aids
Tumor markers in clinical practice Colorectal - CEA Hepatocellular - AFP Pancreatic - CA 19-9 Ovarian - CA 125 Breast -
Ovarian - CA 125 Breast ... Prostate - PSA Germ cell ... Lung (non-small cell ... SCC Lung (small cell ... laboratory #diagnosis #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Rapidly rising blast ... • CML -> AML: Blast ... 10% leukocytes Blast ... Intracellular Urate ... Leukemia #Hematology #Oncology
Primary Bone Tumors - Differential Diagnosis Algorithm Metastatic - Most common tumour in adults - Breast
in adults - Breast ... Non-Malignant • Giant Cell ... Orthopedics #Causes #Oncology
Mastoiditis: Pathogenesis and clinical findings Acute or Chronic Otitis Media -> Stage 1: Hyperemeia of the mastoid
the mastoid air cells ... ) Stage 4: Cell ... into contiguous areas ... postauricular crease ... symptoms #diagnosis #otology
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
ANC <500 x 10^9 cells ... thickening on CT ... segment for at least ... criteria #hematology #oncology
Fournier’s Gangrene - Physical examination was notable for necrotic-appearing tissue in the scrotum and perineum, with
perineum, with areas ... Clinical #Surgery #CT ... #Subcutaneous #NEJM
Proptosis - Differential Diagnosis - Unilateral vs Bilateral Unilateral: • Infections (can become bilateral with cavernous sinus
- Metastatic (breast ... - Langerhans's cell ... Bilateral #Causes #ophthalmology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... suspected) - CT ... chest; CT abdomen ... “big & sticky” cells ... ± tocilizumab; call
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... - gastric and breast ... Chest CT: • Ground-glass ... IgG level X2 at least
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... (GCA) Giant cell ... in literature (NEJM ... cases (Cornelia NEJM ... required +/- prompt ophthalmology
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