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diagnosis differential hyponatremia siadh treatment alkalosis chloride epithelial hypokalemia hypotonic inherited kidney metabolic physiologic tubule urinary
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Inherited Defects ... ascending limb Gitelman ... of epithelial sodium ... #Kidney #Nephrology ... #Differential #Table
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... Hypocalciuria (spot urine ... #nephrology #management ... #pathophysiology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Urinary Chloride Algorithm ... , Gitelman syndrome ... sodium is typically ... the excretion of sodium ... #Algorithm #nephrology
Management of SIADH Treat underlying cause: • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... promoting passive sodium ... Saline: • If Urine ... Has many side effects ... #hyponatremia #nephrology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Urine Na+K / serum ... Cirrhosis, Nephrotic syndrome ... differential #diagnosis #table ... #sodium #nephrology
SIADH Treatment Options 1. Treat underlying cause of SIADH: Pain, Primary lung pathology, Post-operative phenomenon, Medications, Basically
promoting passive sodium ... 0.9% NS • If Urine ... • Major side effects ... SatyaPatelMD #SIADH #Management ... #hyponatremia #nephrology
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