19 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Algorithm Cl- ... , Gitelman syndrome ... the excretion of sodium ... #urine #Algorithm ... #nephrology #differential
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Gitelman's syndrome ... ratio 0.5%) Differential ... #nephrology #management ... #pathophysiology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Diagnosis Algorithm ... Volume Depleted 2° ... , Gitelman Syndrome ... Expanded 1° / 2° ... #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Diagnosis Workup ... Algorithm 1) ... renal mechanism 2) ... #Algorithm #nephrology ... #sodium
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Diagnosis Algorithm ... Volume Depleted - 2° ... , Gitelman Syndrome ... Expanded - 1° or 2° ... #Nephrology #Causes
Hypernatremia Differential Diagnosis Algorithm - Diabetes Insipidus Workup

Step #1 - Consider the history
Step #2 - Assess
Hypernatremia Differential ... Diagnosis Algorithm ... Diabetes Insipidus Workup ... history Step #2 ... #Sodium #nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... Diagnosis Algorithm ... ADH promotes Urea ... Serum Osmolarity 2) ... #nephrology #sodium
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
ascending limb Gitelman ... cell epithelial sodium ... of epithelial sodium ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Metabolic Alkalosis: Differential ... (11-ß HSD type 2 ... furosemide-like lesion) • Gitelman ... Metabolic #Alkalosis #Differential ... Diagnosis #Causes #nephrology