22 results
Algorithm for Differentiating Gitelman syndrome from Bartter syndrome
 • Urine Chloride
 • Urine Ca/Cr ratio

Dr. Krithika
Gitelman syndrome ... from Bartter syndrome ... • Urine Chloride ... #syndrome #Bartter ... #Algorithm #nephrology
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
Urine chloride < 20 mmol/l - Chloride responsive (Chloride
Urine chloride ... diuretic use Urine ... Decreased BP = Bartter's ... Syndrome, Gitelman's ... Syndrome Dr.
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Proximal tubule Bartter ... loop of Henle Gitelman ... #Fanconi #Bartter ... Nephron #Defects #Pathophysiology ... #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Differential Diagnosis Algorithm ... (late) • High Urine ... Cl-: Diuretics, Bartter ... Syndrome, Gitelman ... #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter ... syndrome, Gitelman ... Urine chloride is ... #urine #Algorithm ... #nephrology #differential
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Differential Diagnosis Algorithm ... (late) • High Urine ... Cl-: Diuretics, Bartter ... Syndrome, Gitelman ... #Nephrology #Causes
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... Hypocalciuria (spot urine ... • Bartter syndrome ... • Pseudo Bartter-Gitelman ... #pathophysiology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
volume contracted: urine ... volume expanded: urine ... actively working • Bartter ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... thiazide diuretics, Bartter ... syndrome, Gitelman ... Differential #Diagnosis #Algorithm ... potassium #low #nephrology