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Approach to the diagnosis of chronic hypersensitivity pneumonitis. 
*Consider additional test: bronchoscopy with bronchoalveolar lavage, transbronchial
cHP = chronic hypersensitivity ... pneumonitis; HRCT ... #pneumonitis #pulmonary ... #diagnosis #algorithm ... #HP #ILD
Chronic hypersensitivity pneumonitis
The key findings in chronic hypersensitivity pneumonitis are:
Mosaic pattern with areas of ground-glass atenuation
Chronic hypersensitivity ... atenuation and areas ... The HRCT shows a ... #Clinical #Radiology ... #CXR #CTChest #
On the left two different patients with similarl HRCT findings.
The left one is a smoker with
with similarl HRCT ... the right has hypersensitivity ... the well defined areas ... #Clinical #Radiology ... #CTChest #RBILD
UIP with honeycombing (left) and chronic HP (right)
Differential diagnosis of Hypersensitivity Pneumonitis.
Subacute stage:
- RB-ILD: seen in
Differential diagnosis of Hypersensitivity ... Subacute stage: - RB-ILD ... show very similar HRCT ... Clinical #Diagnosis #Radiology ... #CTChest #UIP #
Basic Interpretation
A structured approach to interpretation of HRCT involves the following questions:
What is the dominant HR-pattern:
reticular
nodular
high
interpretation of HRCT ... bronchiectasis) #Diagnosis #Radiology ... #Pulmonary #HRCT ... #CTChest #Interpretation ... #Algorithm #ILD
On the left a smoker with RB-ILD with subtle HRCT-findings.
The dominant pattern is ground glass opacification.
Additional
with subtle HRCT-findings ... interpretion of the HRCT ... would first think hypersensitivity ... #Clinical #Radiology ... #CTChest #RBILD
On the left a typical case of panlobular emphysema.
There is uniform destruction of the underlying architecture
to widespread areas ... the other hand, mild ... difficult to detect on HRCT ... #Clinical #Radiology ... #CTChest #Panlobular
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
injury • Indirect hypersensitivity ... • Chronic toxicity ... (e.g., chronic ... Exclusion of other ILDs ... confirmatory findings on HRCT
On the left a patient who is treated with cytotoxic drugs for a hematologic malignancy.
The radiographic
like idiopathic pulmonary ... or fibrosis in chronic ... hypersensitivity ... #Clinical #Radiology ... #CTChest #DrugInduced