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syndrome diagnosis hematology leukostasis lysis management tumor tumorlysis uricacid
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... Lysis Syndrome (TLS ... ) Tumor Cell Lysis ... Precipitation => • Urate ... • Hyperkalemia
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... tinnitus, visual changes ... leukapheresis - TLS ... Lysis of tumor cells ... hydration - Hyperkalemia
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