Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine / Xanthine -> Uric Acid (low urinary excretion) -> Allantoin (High urinary excretion) • Phosphorus -> Ca-Phos Precipitation => • Urate Nephropathy (low urine pH) • Ca-Phos nephropathy (high urine pH) • Hypocalcemia • Hyperkalemia #TumorLysis #Syndrome #TLS #Pathophysiology #UricAcid
