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diagnosis differential algorithm anemia management hemolysis hemolytic intravascular leukemia allergy chronic classification cll coagulation cryofibrinogenemia dic dili disseminated druginduced eosinophil
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Increased red cell ... Increased red cell ... Urobilinogen • + urinary ... #Workup #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia • Primary ... • Rheumatic disorders ... effect following treatment ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... unclear, or if a primary ... hematologic disorder ... #Workup #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... /µL Workup • Screen ... glucocorticoid treatment ... Differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphocytes/Mature B cell ... lymphoproliferative disorders ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgM) (e.g. primary ... lymphoproliferative disorders ... Hemoglobinopathies (e.g. sickle cell ... differential #diagnosis #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... biliary obstruction, Primary ... biliary cholangitis, Primary ... Hepatic vascular disorder ... Diagnosis #Algorithm #hepatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Too many cells in ... Better call hematology ... EPO-independent (primary ... up EPO levels Primary ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Workup: • Complete ... Syndromes #diagnosis #hematology ... #oncology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
Eosinophilic GI Disorders ... 3rd pass = Primary ... cell activation ... Mastocytosis • Other hematologic ... Differential #Diagnosis #hematology
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