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hematology leukemia chronic cll differential lymphocytic management agglutinin anemia cold differentiation disease gammopathy hemeonc hemolytic hodgkins lymphoma mds mgus myelodysplasia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... opacities • Diagnosis ... : >3 symptoms, or ... Differentiation #Syndrome #APML ... #hematology #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Monoclonal IgM ... passage of red-brown urine ... • Diagnostic ... hemolytic #anemia #hematology ... #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... rapid onset of symptoms ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... fludarabine) 3) Monoclonal ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Monoclonal Gammopathy ... abnormal intact monoclonal ... constitutional symptoms ... #Significance #hematology ... #diagnosis #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... Differential Diagnosis ... #NonHodgkins #comparison ... #oncology #diagnosis ... #differential #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... Amyloidosis and monoclonal ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... phenomenon CLL Diagnosis ... Transform to DLBCL, PML ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... progression to AML ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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