32 results
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... Initial labs: CBC ... Haptoglobin, LDH, Urine ... Haptoglobin • ↑ Urine ... Management #Algorithm #hematology
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS) Mayo Clinic ... CBC, complete blood ... Followup #algorithm #diagnosis ... #management #hematology
Loiasis - Loa loa Life Cycle
1) Fly (genus Chrysops) takes a meal (L3 larvae enter bite
spinal fluid, urine ... Loaloa #LifeCycle #diagnosis ... #pathophysiology ... infectiousdiseases #cdc ... #parasite
Schistosoma Life Cycle - Schistosomiasis
1) Eggs shed from infected human: in feces, in urine
2) Eggs hatch
: in feces, in urine ... Schistosomiasis #diagnosis ... #pathophysiology ... infectiousdiseases #cdc ... #parasite
Onchocerciasis - Onchocerca volvulus Life Cycle
1) Blackfly (genus Simulium) takes a blood meal (L3 larvae enter
peripheral blood, urine ... OnchocercaVolvulus #LifeCycle #diagnosis ... #pathophysiology ... infectiousdiseases #cdc ... #parasite
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... accumulation of clinical ... salmonella, ...), Parasites ... treatment #summary #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
auricular papules Clinical ... + and CD8+ T cell ... +/CD8+ ratio are ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Emphysematous Cystitis
Epidemiology:
 • Usually middle-aged diabetic women
 • Other RF: neurogenic bladder, urinary tract outlet obstruction,
immune compromise Clinical ... Pathophysiology: ... KUB or abdominal ultrasound ... present • UA and Urine ... pyelonephritis CMC
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... immunophenotype Clinical ... Vmphocytosis on routine CBC ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Bullous Pemphigoid - Diagnosis ... Management Summary Pathophysiology ... epidermis from dermis Clinical ... not feasible CMC ... #Management #dermatology