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Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Involving the Skin ... Vasculitis Skin ... bullae, Ulceration, Urticaria ... - Anti-C1q (Urticarial ... Disease • Cogan syndrome
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Causes == Primary Skin ... • Xerosis (dry skin ... Wheals/Hives: • Urticaria ... == No Primary Skin ... Myelodisplastic syndrome
Clinical manifestations of anaphylaxis. Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache Angioedema: Lips, tongue, orbit,
intestines, extremities Skin ... (Skin and Mucosa ... 80-90%): Urticaria ... arrest, Kounis syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Hypocomplementemic Urticarial ... Vasculitis): - Urticaria ... VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... cryoglobulinemia, urticarial
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Vasculitis, Purpura, Urticaria ... Demyelinating syndromes
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA) Skin ... vasculitis Skin ... also occur Skin ... gangrenosum) • Urticaria ... • Goodpasture syndrome
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... capillary leak syndrome ... Hyperviscosity syndrome ... thrombosis+Pulm HTN+skin ... normo-complementemic urticarial
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Mucocutaneous lymph node syndrome ... Hypocomplementemia: Urticarial ... Hypocomplementemic Urticarial ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy Mild Reaction - Itching, Minor rash
Hypotension, Hives/urticaria ... mucosal involvement, skin ... Stevens-Johnson syndrome ... systemic symptoms syndrome
Strongyloides Stercoralis on sputum microscopy As many suggested this was strongyloides stercoralis hyperinfection syndrome. Infection is initiated by
hyperinfection syndrome ... penetrating the skin ... penetrate the skin ... currens, pruritus, urticaria ... Hyperinfection syndrome
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