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diagnosis differential algorithm pulmonary renal rheumatology vasculitis classification comparison diseases glomerular management pathology prs syndrome syndromes table treatment vasculitides
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... cells on urine microscopy ... nephropathy • Thin GBM ... wall) • Anti-GBM ... nephrotic range) proteinuria
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... #Nephrology #Differential ... Diagnosis #Algorithm #Causes
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Dyspnea, Fever, Hematuria ... polyangiitis, Microscopic ... • Urinalysis (proteinuria ... ab, anti-GBM ab ... differential #diagnosis #nephrology
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Haematuria/nephritis ... Amyloid RPGN • Anti-GBM ... glomerular #diseases #nephrology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
, hematuria) • ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... or gross hematuria ... grade proteinuria
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
multiplex • Hematuria ... , proteinuria, rapidly ... PR3-ANCA): • Microscopic ... tract, and often causes ... glomerulonephritis) • Anti-GBM
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Mononeuritis multiplex • Hematuria ... , proteinuria, Rapidly ... (PR3-ANCA)): Microscopic ... tract, and often causes ... abdominal pain and GN Anti-GBM
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