Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight testing
Transient Proteinuria
• Exercise
• Fever
• UTI
Orthostatic Proteinuria
• Tall adolescents
Tubular Proteinuria (Negative urine dip = no albuminuria)
- Overflow
• Multiple Myeloma
• MGUS
- Poor reabsorption
• RTA
• Fanconi's syndrome
• Drugs
Glomerular Proteinuria (Positive urine dip = albuminuria)
- Active urine sediment - WBC/RBC casts
• IgA nephropathy
• Membranoproliferative GN
• Mesangial proliferative
• Anti-GBM antibodies
• Granulomatosis with polyangiitis (GPA) / microscopic polyangiitis (MPA)
• SLE
• HSP
• Post-infectious GN
- Bland urine sediment
• FSGS
• Minimal change disease
• Membranous nephropathy
• HTN
• Diabetes
• Protein deposition (eg. Amyloidosis)
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