7 results
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
selected glomerular diseases ... Microscopy (EM) ... Minimal change disease ... RPGN • Anti-GBM ... #glomerular #diseases
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
of Glomerular Diseases ... • Breaks in GBM ... #Glomerular #Diseases ... spectrum #diagnosis #nephrology ... #comparison
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Goodpasture's Disease ... anti-ANCA ab, anti-GBM
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... usually low in anti-GBM
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
glomerulonephritis) • Anti-GBM ... disease, and ocular ... (Granulomatous disease ... atherosclerotic disease ... most important diseases
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease)

What is it? A small vessel vasculitis with circulating antibodies directed
Basement Membrane Disease ... (Goodpasture's Disease ... Diagnosis: • Anti-GBM ... Basement #Membrane #Disease ... #pulmonary
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Systemic rheumatic diseases ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE ... pain and GN Anti-GBM