6357 results
Approach to Von Willebrand disease (VWD)

By Matthew Ho, MD PhD @MatthewHoMD

#VWD #Von #Willebrand #VonWillebrand #disease #hematology
Von Willebrand disease ... (VWD) By Matthew ... MatthewHoMD #VWD ... VonWillebrand #disease ... hematology #algorithm #diagnosis
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
also be seen in vWD ... differentiate vWD ... BS by measuring vWF ... Von Willebrand Disease ... #differential #diagnosis
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
- Differential Diagnosis ... in 24h Airway disease ... Coagulopathy: DIC, vWD ... #Differential #Diagnosis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Bone marrow disease ... Von Willebrand disease ... (VWD) • Hypercoagulable ... #Differential #Diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... angioedema • vWD ... Sneddon-Wilkinson disease ... #Differential #Diagnosis
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... Autoantibodies to vWF ... thrombocythemia), Autoimmune disease ... • vWF adsorption ... vonWillebrand #Syndrome #Diagnosis
Diagnostic Schema for Hyperferritinemia

Pearl: Diseases associated with extreme elevations: 
1. HLH 
2. Still's disease 
3. Systemic
Diagnostic Schema ... Hyperferritinemia Pearl: Diseases ... Still's disease ... #Differential #Diagnosis
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Diagnosis VWF ... (Quantity of VWF ... considered to be low) VWF ... of this plasma VWF ... (differentiate VWD
General overview of lung diseases. 

#diagnosis #causes #lung #disease #restrictive #obstructive #pulmonary #respiratory #pearls #ddxof
overview of lung diseases ... #diagnosis #causes ... #lung #disease
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
- Differential Diagnosis ... Syndrome, Celiac Disease ... , Infiltrative Disease ... , Sickle Cell, VOD ... #Differential #Diagnosis