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diagnosis differential algorithm workup bandemia biliary cholangitis cirrhosis elevatedmcv extravascular hemolysis intravascular leukostasis macrocytic macrocytosis management neutrophil pbc primary syndrome
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... count cause hyperviscosity ... limb ischemia, bowel ... signs of end organ ... diagnosis #management #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Neutrophils - Low RBC ... • Small Bowel ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... elliptocytosis - RBC ... immune-complex hemolytic anemia ... Prosthetic heart valves ... #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... appreciate the value ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... Pathophysiology ... intralobular bile ducts causes ... Signs and Symptoms ... diagnosis #workup #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... result in severe anemia ... from ischemia WBC ... Diagnosis #Workup #Hematology
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