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diagnosis feedbackloop growthhormone hematology leukostasis management pituitary tls tumor
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
deficiency: - Short ... Incr fat mass, abn ... - metabolic abn ... #FeedbackLoop #endocrinology ... #pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... priapism • Lab values ... febrile, give abx ... Syndrome: • Pathophysiology ... sudden death • Lab values
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