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Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
major sources of ammonia ... production of ammonia ... elimination of ammonia ... Medications - Valproic ... rare): - Reye syndrome
Ammonium Urate Crystals on Urine Microscopy
Very much like a black sea urchin in these particular examples

Dr.
Ammonium Urate Crystals ... on Urine Microscopy ... @JoseTesser #Ammonium ... clinical #nephrology #urine
Urine Microscopy Crystals
Uric Acid crystals:
 - Formation promoted by acidic urine
 - Seen in tumor lysis
Urine Microscopy ... promoted by acidic urine ... in tumor lysis syndrome ... disease Magnesium ammonium ... independent of urine
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework

Hematologic & Vascular:
 • Multiple myeloma & Acute leukemia (plasma cells
Drugs: • Valproic ... Hyperammonemia #ammonia
Urine Osmolar Gap Calculation

Urine Osmolar Gap represents ammonium salts = Measured Urine Osmolality - (2 x
Urine Osmolar Gap ... Calculation Urine ... Gap represents ammonium ... salts = Measured Urine ... + Urea/2.8) Urine
Types of Renal Calculi

Calcium oxalate
 - Interstitial apatite plaque, Low urine volume, Increased urinary calcium excretion,
apatite plaque, Low urine ... duct plaque, Low urine ... - Magnesium, ammonium ... phosphate: alkaline urine ... Infection with ammonia-producing
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... dysmorphic RBCs in urine ... Nephritic #Nephrotic #Syndrome
Causes Abnormal Urine Color - Differential Diagnosis
Turbid White Urine (Albinuria):
 • Chyluria, Filariasis, Schistosomiasis, Malignancy, Phosphaturia,
Causes Abnormal Urine ... • Drummond's syndrome ... (blue diaper syndrome ... Bag Syndrome - ... Myoglobinuria, Nutcracker syndrome
Urine Anion Gap in NAGMA
NA + K - Cl = surrogate for Urine NH4+
NH4+ is excreted
Urine Anion Gap ... surrogate for Urine ... negative AG implies ↑ ammonium ... ThePeanutKidney #Urine
Distal Renal Tubular Acidosis (RTA)  Type 1 

Totally scuppers the kidney's acidification mechanism. Will be
diagnosis with direct urine ... ammonium assay. ... Failure to acidify urine