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diagnosis management chronic oncology rheumatology aplastic cll differential erythematosus fatigue hemophagocytic hlh leukemia lupus lymphocytic lymphohistiocytosis neurology person sps stiff
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... Arthritis • SLE ... Chronic Fatigue Syndrome
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... life-threatening • Treatment ... #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... • Epstein-Barr virus ... Treatment: ... #oncology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... Treatment: • ... #summary #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... Orange or Hep C Clinical ... • Neutropenia, anemia ... microglobulin Treatment ... #oncology #hematology
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and Management Summary ... Prevalence: 1-2 cases ... and pernicious anemia ... Clinical Manifestations ... antibody that works
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