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diagnosis management oncology rheumatology chronic acute aplastic cll differential erythematosus hemophagocytic hiv hlh leukemia lupus lymphocytic lymphohistiocytosis mds myelodysplasia myelodysplastic
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... Arthritis • SLE ... Syndrome #Chronic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... life-threatening • Treatment ... #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... : • Fever • Fatigue ... and petechiae Causes ... Treatment: ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Symptoms: • Fatigue ... skin that are caused ... Workup: • Complete ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... Orange or Hep C Clinical ... sweats • Extreme fatigue ... • Neutropenia, anemia ... #oncology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Infections+++: Virus ... Autoimmune diseases: SLE ... Treatment: • ... #summary #rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Encephalopathy (25%) • Fatigue ... 14%), in which case ... enzymes ↑ • Mild anemia ... • New onset SLE ... antibody test) Treatment
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
and Management Summary ... Prevalence: 1-2 cases ... and pernicious anemia ... Clinical Manifestations ... antibody that works
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
the most common clinical ... night sweats, and fatigue ... such as: • SLE ... Diagnosis: • Clinical ... affected tissue Treatment
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