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diagnosis hemolytic agglutinin aplastic causes chronic disease leukemoid leukocytosis management testing wbc workup
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Diagnosis Algorithm ... malignancy: • ... bruising/bleeding, fatigue ... hepatomegaly • Labs: anemia ... #hematology #WBC
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
- Differential ... Diagnosis Algorithm ... Neoplastic / Hematologic ... • Anemia • ... Malignancy Infectious
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
disorder or lymphoid malignancy ... Monoclonal - Lymphoid Malignancy ... include fatigue ... younger pts) Differential ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... valve, vasculitis, malignant ... #workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever • Fatigue ... Anticonvulsants - Gold ... immunodeficiency virus ... • Epstein-Barr virus ... #oncology #hematology
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