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Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... response preceding infection ... Decreased / Absent Reflexes ... #Syndrome #diagnosis ... management #treatment #neurology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... #differential #diagnosis ... #table #neurology
NINDS Diagnostic Criteria for Guillain Barre Syndrome 
Features Required for Guillain-Barré Syndrome:
 • Progressive muscle weakness
Criteria for Guillain Barre ... Required for Guillain-Barré ... Recent diphtheritic infection ... #Syndrome #diagnosis ... #criteria #neurology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... to a preceding infection ... depressed deep tendon reflexes ... #Syndrome #diagnosis ... #management #neurology
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
• Malignancy Infectious ... Tuberculosis • Epstein-Barr ... Pulmonary Disease Neurologic ... Myasthenia Gravis Pharmacologic ... Chronic Fatigue Syndrome
Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes simplex virus ... 20%) congenital infection ... disease Epstein—Barr ... #Microbiology #Diagnosis ... #Comparison #Table
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... Wiskott-Aldrich syndrome ... deficiency Infections ... Cytomegalovirus • Epstein-Barr ... virus • Parvovirus
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy
Malignancies
 - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms
Infections
 -
for Differential Diagnosis ... skin neoplasms Infections ... (Epstein-Barr virus ... arthritis, Sjögren syndrome ... #Differential #Diagnosis
Infectious Causes of Adrenal Insufficiency
Anatomical distribution of vessels to the adrenal makes the gland prone to
Infectious Causes ... primary adrenal infection ... Waterhouse-Friderichsen syndrome ... Cytomegalovirus, Epstein-Barr ... #differential #diagnosis
Causes of Myocarditis
Infectious Etiologies:
 • Viral agents: Adenoviruses, Enteroviruses (coxsackievirus), Herpesviruses (human herpesvirus 6, Epstein—Barr virus),
of Myocarditis Infectious ... herpesvirus 6, Epstein—Barr ... disease) Non-Infectious ... Churg-Strauss syndrome ... #differential #diagnosis