13 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... - APLS • Acute ... • Bacterial endocarditis ... Differential #Diagnosis #hematology ... #rheumatology #
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
Hypertension - Workup ... heart failure, neurologic ... Causes: • Vascular ... Neurologic disorders ... #Hypertension #Workup
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Cathepsin G release → vascular ... Imaging: CXR- pulmonary ... Differentiation #Syndrome ... diagnosis #management #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Disruptions in vascular ... Schonlein Purpura - Endocarditis ... deficiency Work ... #dermatology #physicalexam
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Culture Positive: • Acute ... Cerebral > Splenic, Pulmonary ... Cholesterol emboli syndrome ... Septic emboli cause ... Treat underlying cause
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
: • Valvular disorders ... Diagnoses: • Acute ... Coronary Syndrome ... • Infective Endocarditis ... Infarction • Pulmonary
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
disorder (Cardiac, pulmonary ... Impairment: • Acute ... stroke syndromes ... dystrophies Work ... Differential #Diagnosis #neurology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Culture-Negative Infective Endocarditis ... but important causes ... factors: - Serology ... antiphospholipid syndrome ... #differential #workup
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Hyperviscosity, - Vascular ... thrombophlebitis, pulmonary ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pulse deficits vascular ... affects the skin, neurologic ... cognitive impairment, neurologic ... tract, and often causes ... Differential #Diagnosis #Rheumatology