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differential hematology agglutinin ana anemia antibodies cold erythematosus hemolytic leukemia lupus management myopathy myositis neurology neuromyelitis nmo oncology optica patterns
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
neuritis: Reduced visual ... • Extra-CNS complications ... disorders (Systemic ... #diagnosis #neurology ... #symptoms #signs
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... context of other symptoms ... Lymphoproliferative Disorders ... ANA #patterns #rheumatology ... #diagnosis #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... infection, autoimmune ... - Mycoplasma, EBV ... CLL (older) • Autoimmune ... chills, flank pain
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Non-autoimmune ... rheumatologic diseases ... Arthritis: • Joint pain ... Induced Lupus: • Symptoms ... #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... : CNS manifestations ... • Tumor lysis syndrome ... Transformation: • Complication ... #Oncology #Diagnosis
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... disorder) Who ... Sudden onset of pain ... common clinical manifestation ... cases such as: • SLE
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... • Proximal + distal ... • ANA < 20 % IBM ... Extramuscular manifestations ... Myositis #Myopathy #rheumatology
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