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differential management hematology neurology agglutinin anemia arthritis cord erythematosus hemolytic leukemia lupus monoarthritis monoarticular ms msk multiple myopathy myositis oligoarthritis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... infection, autoimmune ... - Mycoplasma, EBV ... CLL (older) • Autoimmune ... chills, flank pain
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... Mechanical/degenerative disorders ... constitutional symptoms ... Rheumatologic Disease ... #Diagnosis #MSK
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Non-autoimmune ... rheumatologic diseases ... pain • Swan neck ... Induced Lupus: • Symptoms ... #Rheumatology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... Sarcoidosis, Behcet disease ... - SLE, Scleroderma ... MCTD, Sjogren syndrome ... differential #algorithm
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , fever, joint pain ... • Tumor lysis syndrome ... Transformation: • Complication ... #Oncology #Diagnosis
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Sclerosis (MS) is an autoimmune-mediated ... neurodegenerative disease ... • Or brainstem syndromes ... impairment, Mood disorder ... Sensitivity to pain
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... claudication, visual ... • Progressive symptoms ... Palpable purpura, joint ... #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... disorder) Who ... Sudden onset of pain ... cases such as: • SLE ... Polychondritis #rheumatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc - Autoimmune ... erythematosus (SLE ... cell lymphoma Pathophysiology ... and the systemic symptoms ... #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... : Fever, joint pain ... • Proximal + distal ... • ANA < 20 % IBM ... Myositis #Myopathy #rheumatology
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