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differential management neurology hematology vasculitis agglutinin algorithm ana anemia antibodies antinuclear arthritis classification cord erythematosus hemolytic leukemia lupus monoarthritis monoarticular
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... infection, autoimmune ... - Mycoplasma, EBV ... CLL (older) • Autoimmune ... chills, flank pain
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... Mechanical/degenerative disorders ... constitutional symptoms ... Rheumatologic Disease ... #Diagnosis #MSK
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... Lymphoproliferative Disorders ... Pulmonary Fibrosis, Multiple ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Non-autoimmune ... rheumatologic diseases ... pain • Swan neck ... • Mononeuritis Multiplex ... Induced Lupus: • Symptoms
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... Demyelinating: - Multiple ... Sarcoidosis, Behcet disease ... - SLE, Scleroderma ... MCTD, Sjogren syndrome
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Sclerosis (MS) is an autoimmune-mediated ... neurodegenerative disease ... • Or brainstem syndromes ... impairment, Mood disorder ... Sensitivity to pain
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... or without back pain ... Bilateral signs and/or symptoms ... Evaluate for NMO, SLE ... suggestive of multiple
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... claudication, visual ... • Progressive symptoms ... Palpable purpura, joint ... #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , fever, joint pain ... • Tumor lysis syndrome ... Transformation: • Complication ... #Oncology #Diagnosis
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... disorder) Who ... Sudden onset of pain ... cases such as: • SLE ... , MDS & Multiple
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