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diagnosis hematology causes disease hemolytic intravascular agglutinin cold erythematosus laboratory pulmonary renal rheumatic rheumatoid sle syndrome systemic testing workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... • Intrinsic RBC ... #Causes #differential ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... Diagnosis Algorithm ... elliptocytosis - RBC ... anemia • ... #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... Blood smear - RBC ... younger pts) Differential ... passage of red-brown urine ... #anemia #hematology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Fever, Hematuria, Hemoptysis ... polyangiitis, Microscopic ... Complex: Systemic lupus ... erythematosus, Rheumatoid arthritis ... #diagnosis #nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... edema, active urine ... lymphopenia, low PLT • Anemia
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
polarized light microscopy ... joint • Systemic lupus ... the presence of anemia ... • Serum and urine ... ANA and RF (if clinical
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