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oncology differential causes chronic cll hemolytic leukemia lymphocytic workup abnormal activation agglutinin aplastic atlas cancer classification coagulation cold dic disease
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... • Intrinsic RBC ... Defects: Enzyme ... #hematology #anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Thrombotic idiopathic thrombocytopenia ... , Disseminated intravascular ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Treatment: ... result from low blood ... #oncology #hematology ... #diagnosis #management
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... value for this enzyme ... of Peripheral blood ... from ischemia WBC ... #Workup #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... ABO incompatible blood ... organ damage Clinical ... #Coagulation #diagnosis ... #management #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... 5) Symptoms of anemia ... or thrombocytopenia ... Leukemia #oncology #hematology ... #management
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... presence of metabolic syndrome ... the magnitude of enzyme ... body mass index; FBC ... #Hepatology #Liver
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... sensitize red blood ... the RBCs causing intravascular ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Neutropenia, anemia ... , thrombocytopenia ... microglobulin Treatment ... workup #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
with leukopenia, anemia ... , and thrombocytopenia ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
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