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differential abnormal intravascular pt anemia bleeding blood bruising disseminated extravascular hemolysis hemolytic hemostasis leukostasis lysis product syndrome tls transfusions treatment
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... (DIC) c. ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... protein C and S Pathophysiology ... #diagnosis #causes ... #treatment #management ... #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... #hematology #anemia
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... • Lab values: WBC ... Syndrome #TLS #diagnosis ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... the PT remains prolonged ... discern these causes ... #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... Causes purpura & ... TRALI): Leading cause ... #Transfusions #diagnosis ... #management #hematology
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