23 results
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Diagnosis Algorithm ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Hyperthyroidism CBC ... Myelodisplastic syndrome
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
arterial HTN) • Renal ... : scleroderma renal ... #diagnosis #signs ... #symptoms #testing ... #workup
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Diagnosis for Pulmonary ... Renal Syndromes ... Immune Complex: Systemic ... #Syndrome #differential ... #diagnosis #nephrology
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
GI losses - Chronic ... Hypomagnesemia #Differential ... #Diagnosis #Low ... #Magnesium #Table ... Classification #Causes #Workup
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
- Differential ... Diagnosis Framework ... Malabsorption, Chronic ... FEPO4 ≥ 5% - Renal ... #nephrology
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
arthralgias, CV, renal ... Hypereosinophilic Syndrome ... Diseases #pulmonary #differential ... #diagnosis #comparison ... #table #eosinophilia
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
discoloration) • Chronic ... renal failure ... • Nephrotic syndrome ... #Differential # ... Diagnosis #Algorithm
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Creatinine & BUN: • Chronic ... renal failure/uremia ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... Pruritus #secondary #systemic
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... mononeuritis multiplex WORKUP ... w differential ... or serologies + symptoms ... #Syndromes #differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... : >3 symptoms, or ... initiation • Differential ... Anaphylaxis, Acute Renal ... #management #hematology