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management oncology differential anemia workup abnormal agglutinin algorithm aplastic apml causes chronic cll cold differentiation disease disorders enzymes hemolytic hepatopulmonary
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... Dehydration • Symptoms ... • Lab values: WBC ... #TLS #diagnosis ... #management #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... pylori test (GI symptoms ... (CVID, WAS), (neurologic ... #Differential #Diagnosis ... Causes #Workup #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... if high risk if WBC ... : >3 symptoms, or ... QD until normal WBC ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... • Improve the symptoms ... Anemia #oncology #hematology ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... (Cold-induced symptoms ... Blood smear - RBC ... hemolytic #anemia #hematology ... #diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... et diutinum Neurologic ... +Organomegaly+↑RBC ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... phenomenon CLL Diagnosis ... Lymphocytosis on CBC ... • Richter’s Syndrome ... workup #oncology #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
suspicious clinical symptoms ... presence of metabolic syndrome ... Areas of diagnostic ... body mass index; FBC ... Abnormal #Algorithm #Hepatology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... Arterial blood gas (ABC ... resolution of symptoms ... hepatopulmonary #syndrome ... #treatment #hepatology
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