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differential causes abnormal anemia primary transaminitis approach arthritis chemistry cholangitis disorders elevated enzymes gap globulin hemolytic hepatitis hepatopulmonary hps injury
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... Pathophysiology ... #Cirrhosis #PBC ... #workup #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Cirrhosis - Diagnosis ... #PBC #Primary ... #Biliary #Cirrhosis ... #Diagnosis #Algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... hepatitis: < 1 • Cirrhosis ... • LDH: Heart, RBC ... #algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Ducts - PBC ... - CBD stone, Biliary ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs Decreased RBC ... Disease • Marrow ... Thalassemia • RBC ... Disorder • RBC ... #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Cholestatic disease ... Duct Stone • Biliary ... • Others #LFTs ... #Hepatology #LiverEnzymes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... smear, HIV/HCV testing ... (liver disease) ... , HBsAg/anti-HBc ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Algorithm #workup ... #hematology #testing
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #chemistry #diagnosis ... #differential #Hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
decision for repeat testing ... include extrahepatic biliary ... body mass index; FBC ... #LFTs #Abnormal ... #Algorithm #Hepatology
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