9 results
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Algorithm Vascular Causes ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... : Autoimmune hepatitis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential ... Highest • Bone • Liver ... Intestine - Other causes ... elevation DDX of Hepatic ... biliary Cholangitis (PBC
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
↑ LDH • Anti-RBC ... • Blood smear: Differential ... 2) LOOK FOR a cause ... #diagnosis #management ... #treatment #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... Labs: • Alkaline ... bile ducts Differential ... malignancies, Hepatic ... cholangitis #diagnosis #workup
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
diagnosis and treatment ... and hematologic ... ALT, alanine aminotransferase ... hemochromatosis; HIC, hepatic ... algorithm #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... +++ (Plt, Hb), Hepatic ... solid cancers • Autoimmune ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... platelets - WBC ... #oncology #management
Fever After International Travel

Infectious Disease:
• Endemic in either the destination or home region

Viral Syndromes:
Arboviral infections, a
elevations in hepatic ... No hemolytic anemia ... Investigations: • CBC ... including tests of liver ... #Travel #Differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... Sarcoidosis) • Liver ... Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... Gap #ProteinGap #differential