11 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - ... ) (e.g. lupus, CLL ... . primary cold agglutin ... • Intrinsic RBC ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Anemia #Differential ... #workup #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... Blood smear - RBC ... #disease #hemolytic ... #anemia #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... 3) Internal (RBC ... Urobilinogen #Hemolysis ... Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Hemolysis ... (hemolysis, bleeding ... • LDH: Heart, RBC ... (hemolysis) • ... #hepatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Anemia Clinical ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... aplasia • ITP ... #workup #oncology ... #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... +Organomegaly+↑RBC ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Aplastic Anemia ... blood count with differential ... #diagnosis #hematology ... #oncology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... platelets - WBC ... classification #hematology