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diagnosis differential hematology leukemia liver causes acute biliary chemistry diffuse gap globulin hemeonc hepatitis hepatopulmonary hps interpretation lad lfts lymphadenopathy
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
(Pancytopenia, WBC ... Age > 50 • Chronic ... (CBC with Lymphocytes ... ) - Monoclonal ... #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... chemotherapy for low-risk disease ... fludarabine) 3) Monoclonal ... #Chronic #Lymphocytic ... #Leukemia #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... (Chronic Lymphocytic ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... cells can indicate disease ... #Chronic #Lymphocytic ... diagnosis #workup #oncology ... #hematology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary Cirrhosis ... female-predominant disease ... of autoimmune disease ... mediated BEC injury ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... vein: Budd-chiari syndrome ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... #hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... +Organomegaly+↑RBC ... Sneddon-Wilkinson disease ... #Diagnosis #Oncology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... obstruction, HELLP Syndrome ... Malignancy, 1° PBC ... Causes #Acute #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... • Gilbert's syndrome ... #differential #Hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... • Heavy chain disease ... changes (POEMS syndrome ... : Cirrhosis, ETOH ... autoimmune hepatitis, PBC
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