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rheumatology chronic classification leukemia lupus lymphocytic syndrome workup acidosis common comparison cvid dermatology differential druginduced erythematosus hemeonc hemophagocytic hlh hodgkins
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
SLL CLL Epidemiology ... Orange or Hep C Clinical ... • Neutropenia, anemia ... #workup #oncology ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Differential Diagnosis ... lymphoma • Evans ... lymphopenia, low PLT • Anemia
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... Arthralgia and Arthritis ... • B cell lymphoma ... #Diagnosis #Management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... lymphoma (Richter ... chemotherapy for low-risk disease ... #hematology #hemeonc ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... platelets - WBC ... number of sites of disease ... #hematology #oncology ... #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... lymphoma, B-cell ... : SLE+++, Adult-onset ... Drugs, Unknown cause ... #management #treatment
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Causes: - Idiopathic ... (malignancy), lymphoma ... - CBC may also ... #dermatology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... ) • Systemic granulomatous ... DDX - Other causes ... #diagnosis #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... Discontinuation of causal ... months to years) Systemic ... : Chronic disease ... #diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... Screening Tests for All ... the presence of anemia ... (to support a diagnosis ... ANA and RF (if clinical
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