14 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal or low ... Hypocalciuria (spot urine ... #diagnosis #nephrology ... #management #pathophysiology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
↓ Aldosterone: Syndrome ... excess, Liddle's syndrome ... Diuretics, Bartter syndrome ... , Gitelman syndrome ... #potassium #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... the indicated causes ... #nephrology #differential
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
usually caused by ... Measure urine osmolality ... demyelination syndrome ... #Differential # ... #management #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
volume-based algorithm Urine ... Present (Uosm ≥100): Hypovolemia ... Cirrhosis, Nephrotic syndrome ... #differential # ... table #sodium #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Compartment syndrome ... Neuroleptic malignant syndrome ... or compartment syndrome ... #causes #treatment ... #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... count cause hyperviscosity ... syndrome • Triggers ... rasburicase Tumor Lysis Syndrome ... #Tumor #Lysis #Syndrome
Hyponatremia - Differential Algorithm
Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP
Hypotonic Hyponatremia: 
 • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Hyponatremia - Differential ... : • Hypovolemia ... Euvolemia: SIADH, Beer ... Cirrhosis, Nephrotic Syndrome ... #low
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... hour with goal urine ... Dialysis for severe hyperkalemia ... #Summary #causes
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
draw, ↑↑Plts or ↑↑WBC ... lysis) ± Urine ... only if no clear cause ... acidosis) • Low ... #nephrology #K