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hematology differential management algorithm dermatology mds pruritus activation aplastic endocarditis infectiousdiseases leukemia macrophage monoclonal myelodysplasia primary
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... Hyperviscosity syndrome ... CVST • Bing-Neel syndrome ... (Dermato-neuro syndrome ... dermatosis) • Gleich syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - ... cytopenias (usually anemia ... #Syndrome #MDS ... #treatment #hematology ... #oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... Pruritus #primary #secondary ... #systemic #generalized
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... DDX: Rule Out Secondary ... Causes • Anemia ... #Syndromes #diagnosis ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... syndrome (MDS) ... #oncology #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #Pruritus #secondary ... #systemic #generalized ... #Algorithm #causes
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... among the secondary ... Periodic fever syndromes ... hypersensitivity syndromes ... Macrophage #Activation #Syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL: mediastinal mass ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Generalized: Chills ... Cholesterol emboli syndrome ... Leukocytosis, anemia ... hematuria, + RF Treatment ... #cardiology #infectiousdiseases
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