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hematology oncology agglutinin causes chronic cll cold disease erythematosus extravascular hemolysis hodgkins intravascular leukemia lupus lymphocytic management monoclonal nephrotic paraproteinemias
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... e.g. lupus, CLL, lymphoma ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... #Diagnosis #Algorithm
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
glomerulonephritis; HUS = hemolytic-uremic ... TTP = thrombotic thrombocytopenic ... #Algorithm #differential ... #diagnosis #glomerular ... #nephrology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... nodosum • Immune hemolytic ... Workup: • Full ... platelets - WBC ... #diagnosis #classification
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... • Neutropenia, anemia ... , thrombocytopenia ... #workup #oncology ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... • Coombs (-) hemolytic ... anemia due to cold ... #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Skin Disease Classification ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... #Rheumatology
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