12 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... fraction < 20% Differential ... solid cancers • Systemic ... Disease #diagnosis #management ... #treatment #rheumatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... - HCV - HIV ... • ↓ WBC • ↓ ... Anemia #oncology #hematology ... #diagnosis #management
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
meningococcal, H1N1) Clinical ... Guillain-Barre Clinical ... • Weakness: Starts ... - NORMAL CSF WBC ... #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... • Cogan Syndrome ... Lab Tests: • CBC ... Cryoglobulins • HIV ... #diagnosis #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Systemic disease ... (Clinical Dx). ... Behcet disease) Differential ... #diagnosis #management ... signs #symptoms #rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune system ... Agent Orange or Hep ... C Clinical Presentation ... Lymphocytosis on CBC ... ’s CLL Scoring system
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Clinical Features
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... Central nervous system ... Cytopenia: 2% Systemic ... #Rheumatology # ... Diagnosis #Management
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... hemolytic anemia) • Systemic ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... #diagnosis #management
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Blood smear - RBC ... Mycoplasma, EBV, HIV ... younger pts) Differential