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differential causes oncology elevatedmcv generalized macrocytosis microcytic pruritus secondary systemic aplastic atlas chronic cll gap hemolytic key lymphocytic management mds
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... wide range of RBC ... #Algorithm #Diagnosis ... #Workup #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Bleeding gastric ulcer ... coagulopathy (DIC) #RBC ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Algorithm Normal ... Neutrophils - Low RBC ... Myelodysplastic Syndromes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Chronic Myelogenous Leukemia ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
- Fe/TlBC, MCV/RBC ... TIBC Normal - MCV/RBC ... inclusions in RBC ... #Microcytic #Anemia ... #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... , thrombocytopenia ... #diagnosis #workup ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Schistocytes, thrombocytopenia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #Algorithm #workup ... #hematology #testing
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... antithymocyte globulin ... #oncology #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... Hyperthyroidism CBC ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
renal failure/uremia ... Hyperthyroidism CBC ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology
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