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hematology differential testing chronic hemolysis leukemia lymphocytic management nephrology nephrotic agglutinin algorithm atlas causes classification cold extravascular gammopathies gap globulin
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoid malignancy (CLL ... Diagnosis: • hemolytic ... malignancies - B-cell ... #hemolytic #anemia ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... ) (e.g. lupus, CLL ... Hemoglobinopathies (e.g. sickle cell ... #hematology #anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... - Sickle cell anemia ... uremic syndrome ... Morphology #Atlas #key #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Algorithm • Sickle cells ... Consider sickle cell ... #workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... marrow plasma cell ... , B and T cell lymphoproliferative ... diseases, CML, ... #hematology #oncology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell ... anemia, Thalassemias ... #hematology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
disease 24- ... LDH - Assess for hemolysis ... decreased red cell ... #testing #workup ... #diagnosis #glomerulonephritis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Transformation to large cell ... chemotherapy for low-risk disease ... fludarabine) 3) Monoclonal ... uw_IMresidency #CLL
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... • Coombs (-) hemolytic ... anemia due to cold ... #Diagnosis #Oncology
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